Institut Curie

About the Company

Fondation reconnue d’utilité publique, l’Institut Curie associe l'un des plus grands centres de recherche européens en cancérologie et deux établissements hospitaliers de pointe.

Fondé en 1909 sur un modèle conçu par Marie Curie et toujours d’avant-garde, «de la recherche fondamentale aux soins innovants», l’Institut Curie rassemble 3 000 chercheurs, médecins, soignants, techniciens et administratifs.

Les soins
L'Ensemble Hospitalier de l’Institut Curie est un centre de référence pour les cancers du sein, les tumeurs de l’œil et les cancers pédiatriques notamment.

La recherche
Pour faire progresser la prévention, le diagnostic et le traitement des cancers, biologistes, chimistes, physiciens, bio-informaticiens et médecins se mobilisent, dans une démarche multidisciplinaire de recherche pour lutter contre le cancer.
Les recherches fondamentales, translationnelles et cliniques sont autant de moyens que l'Institut Curie déploie dans son Centre de Recherche, son département de Recherche translationnelle et son Ensemble Hospitalier pour faire progresser la cancérologie.

Listed Jobs

Company Name

Institut Curie

Job Title

Post doctoral / Engineer position in radiation protection (M/F)

Job Description

About Us

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 3000 employees with a strong international representativeness. The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

The Orsay Proton therapy Center (CPO) founded in 1991 is part of the radiation oncology department at Institut Curie hospital group, which is one of the European-wide recognition as a Comprehensive Cancer Center of excellence. This position will be associated with a research project at Institut Curie whose goal is to develop new treatment delivery methods for very-high energy electrons (VHEE) treatments, and their application to FLASH radiotherapy, and is an exciting opportunity to join the radiation therapy research activities in Orsay, within the hospital and the research center.

Mission

Laboratory

The Laboratory of Translational Imaging in Oncology (LITO) is a research unit (U1288) supported by Inserm (= French NIH) and Institut Curie, the first cancer center in France (https://www.lito-web.fr/). LITO has approximately 30 researchers, including physicists, engineers, physicians, pharmacists, and technologists.

Context

Radiation therapy is currently one of the main techniques used for cancer treatment. More than 50% of patients treated for cancer - about 180,000 per year in France - benefit from it. Over the last thirty years, numerous technical advances have made it possible to considerably improve the conformation of irradiation to the specific characteristics of each tumour and to reduce their side effects. Nevertheless, the tolerance of healthy tissues remains the main limitation of this type of treatment, particularly in the case of particularly radiosensitive patients, such as children, for whom controlling the side effects of radiotherapy remains a major therapeutic challenge. Recently, pioneering work conducted at Institut Curie has shown that ultra-high dose rate irradiation (known as FLASH) has a major effect in sparing healthy tissue - while preserving anti-tumor efficacy (Favaudon et al 2014).

VHEE radiotherapy (very-high energy electrons, in the energy range of 100 to 250 MeV), first proposed in the 2000s, would be particularly accurate and independent of tissue heterogeneities (unlike low energy electrons or protons), and could be applicable in a large number of deep anatomical localizations. It is also potentially much less expensive than other radiotherapy techniques, and would allow accelerated treatment, for example through magnetic scanning of particle beams, with high doses per fraction, thereby improving its effectiveness. It is also possible to take advantage of recent work on FLASH - in which a high dose is administered to the tissues in an extremely short time - allowing the simultaneous reduction in the occurrence and severity of early and late complications affecting normal tissues, while maintaining control of the tumour (Ronga et al 2021).

It is however important for the clinical development of VHEE electron beams to consider the contribution to the equivalent dose received by the patient of neutrons, photons and induced radioactivity at very high energy, and to evaluate the production of neutrons, photons and radioactivity from the radiation protection point of view (patients and workers). As Monte Carlo techniques are the golden standard for radiation transport calculations, the applicant will therefore simulate the irradiation and possible contribution from secondary particles during VHEE treatments, and assess the feasibility of VHEE irradiation within standard radioprotection levels in a conventional bunker.

Profile

Candidate Profile

The candidate must hold a PhD or Master degree in radiation physics, medical physics or detection physics

Radiation­ matter interactions / radiation therapy / dosimetry
Preferred expertise and experience in one or more of the following areas: programming skills (MATLAB, Python, C++) – Monte Carlo simulations (ex: Geant4/TOPAS) – Measurements – Treatment planning. You will also be expected to have experience in working as part of a multidisciplinary team.

All Our Opportunities Are Open To People With Disabilities

Contract information

Type of contract: Fixed-term contract.

Starting date: as soon as possible

Duration: 24-36 months

Working time: full time- number of days

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Orsay

Reference: NA

Contact

Please apply by e-mail (CV + application letter + references/support letter) to

Publication date: April 4, 2025

Deadline for application: June 30, 2025

References

V. Favaudon, L. Caplier, V. Monceau, F. Pouzoulet, M. Sayarath, C. Fouillade, M. F. Poupon, I. Brito, P. Hupe, J. Bourhis, J. Hall, J. J. Fontaine, M. C. Vozenin, Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumour tissue in mice, Sci Transl Med 6 (2014) 245ra93.

Ronga, M. G., Cavallone, M., Patriarca, A., Leite, A. M., Loap, P., Favaudon, V., Créhange, G., & De Marzi, L. (2021). Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy. Cancers, 13(19), 4942.

Lagzda, A. VHEE Radiotherapy Studies at CLARA and CLEAR Facilities (The University of Manchester, 2019).

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf

Référence de l'offre : f43g3ccahx

Orsay, France

Hybrid

04-04-2025

Company Name

Institut Curie

Job Title

Bio-informatician in immunology (M/F)

Job Description

À propos de nous

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Mission

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France, https://institut-curie.org/team/piaggio) is seeking a degree-qualified computational scientist. The bioinformatician will be dedicated to work on several projects in the frame of fundamental and translational immunology research, including neoantigen epitope prediction, CD8+ and CD4+ Tconv and Treg cell biology and anti-tumor responses. Candidate will join our Team-bioinformatician hub of around 5 people and will benefit from Institut Curie bioinformatics platform.

Missions

Tasks will include analysis of large datasets generated from single cell RNAseq, TCRseq, and ATACseq, spatial transcriptomics, whole exome sequencing, bulk expression studies, and AI development and application.

Profil

Training And Experience Required

Candidates should have a Ph.D. in bioinformatics, mathematics, computer sciences, immunology, or related field. She/he should have demonstrated success in a previous research experience in immunology-applied bioinformatics and statistics testified by publications.

Skills Required

Knowledge in approaches for high-throughput data analysis, statistical modeling, and classification, as well as basic understanding of immunology are required. Previous experience with single cell RNASeq / TCRSeq will be a plus.

Strong motivation, autonomy and ability to quickly and effectively adapt to new projects will be essential.

Good proficiency in English is mandatory.



All Our Opportunities Are Open To People With Disabilities



Contract information

Type of contract: Fixed-term contract / COD

Starting date: as soon as possible

Duration: 18 to 36 months

Working time: full time

Remuneration: according to the current grids and dependent on experience

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Please send your CV and letter of motivation.

Publication date: 07/04/2025

Deadline for application: 30/06/2025

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

Référence de l'offre : 53q7eoca1d

Paris, France

Hybrid

07-04-2025

Company Name

Institut Curie

Job Title

Post-doctorat en data science/ physique médicale (H/F)

Job Description

À propos de nous

L'Institut Curie est un acteur majeur de la recherche et de la lutte contre le cancer. Il est constitué d'un hôpital et d'un Centre de recherche de plus de 1000 collaborateurs avec une forte représentativité internationale.

L’objectif du Centre de recherche de l’institut Curie est de développer la recherche fondamentale et d’utiliser les connaissances produites pour améliorer le diagnostic, le pronostic, la thérapeutique des cancers dans le cadre du continuum entre la recherche fondamentale et l’innovation au service du malade.

Mission

Laboratoire

Le Laboratoire d’Imagerie translationelle en Oncologie (LITO) est une unité de recherche (U1288) soutenue par l’Inserm et l’Institut Curie, (https://www.lito-web.fr/). Le LITO compte environ 30 chercheurs, dont des physiciens, des ingénieurs, des médecins, des pharmaciens et des techniciens. Le Centre de protonthérapie d'Orsay (CPO), fondé en 1991, fait partie du service de radiothérapie-oncologie du groupe hospitalier de l’Institut Curie, qui est l'un des centres d'excellence reconnus au niveau européen comme Comprehensive Cancer Center.

Poste à pourvoir

La radiothérapie est actuellement l'une des principales techniques utilisées pour le traitement du cancer. Au cours des trente dernières années, de nombreuses avancées techniques ont permis d'améliorer considérablement la conformation des irradiations aux caractéristiques spécifiques de chaque tumeur et de réduire leurs effets secondaires. Néanmoins, la tolérance des tissus sains reste la principale limite de ce type de traitement, notamment dans le cas de patients particulièrement radiosensibles, comme les enfants, ou de tumeurs radiorésistantes pour lesquelles le contrôle des effets secondaires de la radiothérapie reste un défi thérapeutique majeur.

Le développement d'approches innovantes qui réduisent la sensibilité des tissus sains à l'irradiation tout en maintenant l'efficacité du traitement sur la tumeur est donc d'une importance cruciale pour le progrès de l'efficacité de la radiothérapie. Récemment, des travaux pionniers menés à l'Institut Curie ont démontré que l'irradiation à très haut débit de dose ou la radiothérapie spatialement fractionnée pouvaient avoir un effet majeur d'épargne des tissus sains tout en préservant l'efficacité anti-tumorale.

Au sein du département de radiothérapie et de l'équipe LITO basés à l'Institut Curie-Hôpital à Orsay (91), l'équipe de physique médicale recrute un post-doctorant, avec un fort intérêt pour la recherche translationnelle sur le traitement du cancer. Dans le cadre des activités de ce projet, le candidat devra exploiter l'apprentissage automatique et profond pour prédire la réponse des patients au traitement ainsi que la toxicité de la radiothérapie, en particulier dans le contexte de techniques de radiothérapie innovantes (FLASH, protons, VHEE).

Les Tâches Seront Les Suivantes

L'utilisation de la radiomique et de l'apprentissage automatique/approfondi pour prédire la réponse des patients au traitement du cancer, en mettant l'accent sur l'intégration des calculs d'incertitude et des méthodes d'explicitation/interprétabilité des modèles.
Analyser de grands ensembles de données de haute qualité en utilisant un enregistrement d'image innovant, l'apprentissage automatique et les caractéristiques de la dose (radiomique basée sur la dose), afin de développer des modèles mathématiques qui pourraient être utilisés pour prédire et éviter les principaux paramètres de morbidité/toxicité dans la planification du traitement par radiothérapie.
Effectuer des évaluations et des validations approfondies des algorithmes développés à l'aide d'ensembles de données cliniques.
Contribuer à la documentation et à la diffusion des résultats de la recherche par le biais de rapports et de présentations.

Profil

Le/la candidat.e doit être titulaire d'un doctorat, de préférence en science des données, au sein des applications et/ou des développements de l'IA en radiothérapie/physique médicale, ou dans une discipline connexe.

Compétences

Compétences en programmation (MATLAB, Python, C++, TensorFlow, PyTorch) statistiques multivariées ;
Apprentissage automatique ;
Apprentissage profond et IA explicable.

Vous devrez également avoir de l'expérience dans le travail au sein d'une équipe pluridisciplinaire.

Toutes nos opportunités sont ouvertes à des personnes en situation de handicap.



Type de contrat: CDD.

Date de démarrage: dès que possible

Durée du contrat: 24 mois

Temps de travail: temps plein

Rémunération: selon les grilles de salaires en vigueur

Avantages: Restauration collective, prise en charge du titre de transport annuel à 70%, mutuelle d’entreprise

Localisation du poste: Orsay

Si vous souhaitez candidater, merci d'envoyer CV et lettre de motivation.

L'Institut Curie est un employeur inclusif respectant l'égalité des chances. Il s’engage également à appliquer des normes exigeantes en matière d'intégrité de la recherche.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf

Référence de l'offre : zdolwsinnh

Orsay, France

Hybrid

17-04-2025

Company Name

Institut Curie

Job Title

Bioinformatic scientist (IE/IR)

Job Description

About Us

The Institut Curie Research Center

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Mission

Context and laboratory

In the frame of the Paris Kids Cancer consortium, a trans-IRPs project is funded that aims at constructing and characterizing a cellular atlas of pediatric cancers based on single-cell transcriptomics and exploring the relationships between development, immune cells and tumor cell phenotypes. To consider both intra-tumor heterogeneity (within tumors) and inter-tumor heterogeneity (between patients), the project will first integrate single-cell RNA-seq data of tumor cells from several pediatric cancer types to further investigate commonalities and relationship between transcriptional and signaling networks. Tumor cell data will be compared to single-cell atlas of normal cells during development that are already published and/or to data generated in the frame of PKC. All non-malignant populations will be integrated from available pediatric malignancies to explore the commonalities and differences of the various populations of the tumor microenvironment with a strong focus on immune cells.

This project offers a unique opportunity to participate in the understanding of tumor initiation and progression of pediatric cancers. The collaborative aspect of the project and interactions with the various teams of the PKC consortium will create a highly synergistic environment. Two bioinformatic scientists will be recruited for the project, one being based at Institut Curie and one being based at Gustave Roussy.

Missions

The Candidate Will

Actively participate in the development of a common analysis pipeline to obtain robust count tables from single-cell transcriptomic raw data.
Run the analysis pipeline on various single-cell RNA-seq datasets obtained in-house and other teams of the PKC consortium as well as published/external datasets.
Use and/or develop methods and strategies to explore the data in close collaboration with biologists. One key aspect will be to perform various integrations of filtered data to address tumor cell phenotypes, links with normal cells of the development and characterize non-malignant populations of the tumor microenvironment.
Actively participate in the preparation of a dedicated Web server to share the various atlases.
Present in team meetings.

The candidate will be supervised by the researchers leading the PKC pan-pediatric atlas project at Institut Curie (Dr Isabelle Janoueix-Lerosey and Dr Joshua Waterfall). This project will be performed in close collaboration with researchers leading the project at Gustave Roussy (Dr Thomas Mercher and Dr Florent Ginhoux).

She/he will benefit from daily exchanges with people working on pediatric cancers and computational biologists with strong expertise. Additionally, the candidate will have the opportunity to interact with the broader bioinformatics community at Institut Curie through the Curie Bioinformatics Hub.

Profile

Candidate profile

Training And Experience Required

Master degree in Bioinformatics or related fields with at least 2 years experience
or PhD in Data Science, Bioinformatics or related fields.

Skills Required

Solid skills in handling NGS datasets
Solid experience in bash and R/python (other programming languages are a plus)
Experience with working in an Unix environment
Experience with working on a computer cluster would be a plus
Good working knowledge in cancer biology would be a plus
Highly motivated and able to collaborate with biologists and bioinformaticians of the whole project
Good skills in written and oral English would be a plus (knowing French is not necessary if the candidate has a good level in English)

All Our Opportunities Are Open To People With Disabilities

Type of contract: Fixed-term contract for IE/IR

Starting date: June 2025

Duration: 18-month term position with the possibility of 18-month extension based on performance

Working time: full time

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, RTT days

Location of the position : Centre de Recherche Paris, Bâtiment Trouillet-Rossignol, 26 rue d’Ulm, 75005 Paris

If you want to apply, please send your CV and motivation letter.

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf

Référence de l'offre : mf6zw38hdq

Paris, France

Hybrid

17-04-2025