Bioinformatician
Hybrid
Cheadle, United Kingdom
Freelance
13-04-2025
Job Specifications
Application Deadline: 19 May 2023
Department: Access
Location: Cheadle
Compensation: £40,000 - £48,000 / year
Description
Overview Of The Role
Working hours are 35 hours per week, Monday to Friday.
As Bioinformatician you will develop analytical pipelines and processes to manage large-scale –omics projects, especially focussing on whole-genome sequencing and whole-exome sequencing. Work will be largely in support of current projects to sequence genomes and exomes for all 500,000 participants in the cohort, and is anticipated to develop into other –omics work as projects develop. To maintain and document existing workflows, and integrate processes into the new UK Biobank Research Analysis Platform, a cloud-based platform developed with DNANexus to enable analysis of large-scale genomic data and the existing UK Biobank phenotypic resource.
Responsibilities
UK Biobank is seeking a suitably qualified and experienced individual to provide bioinformatic development and support for ongoing large-scale sequencing and imaging projects on 2 year fixed term contract. The main responsibilities will involve processing and analysing sequencing data and development of bioinformatics pipeline's for research use, including:
Development of additional quality control procedures for whole-genome and whole-exome sequencing data
Incorporation of existing algorithms for data processing into the UK Biobank Research Access Platform
Development of procedures to derive phenotypic measures from MR and DXA imaging
The post will be based at our modern offices Cheadle, although regular liaison with UK Biobank staff at the Big Data Institute (at the University of Oxford) will be required.
The post-holder will work closely with a multi-disciplinary team of programmers, statisticians, epidemiologists, data analysts, research and administrative staff and will report to UK Biobank's Senior Data Analyst based in Cheadle.
This is an exciting opportunity to interrogate and resolve issues and challenges associated with generating sequencing and imaging at a previously unprecedented scale, and highly complex real-world data sets and applications
The role will suit an enthusiastic, talented, and self-motivated individual with proven skills in bioinformatics and working with big data.
Essential
About you
PhD in bioinformatics or related field, or equivalent experience
Significant experience in analysis of large-scale sequencing data, including complex multistage pipeline development, reporting, and troubleshooting
Proficiency in programming, e.g. Python/C++/R, and familiarity with containerisation (e.g. Docker), command line applications, and programming standards such as version control
Excellent problem solving and analytical skills, and ability to prepare and maintain detailed documentation.
Ability to prioritise workload and to work under pressure
Highly motivated with excellent attention to detail, able to work on own initiative and as part of a multi-disciplinary team.
Proficiency in using relational databases and writing SQL queries.
Excellent written and oral communication skills in English, with the ability to present to technical and non-technical audiences.
Desirable
Previous experience working with imaging data formats, such as DICOM or NIFTI
Proficiency in workflow management systems (e.g. Nextflow, SnakeMake, CWL, WDL)
Experience of machine learning (ML) approaches for data analyse
Understanding of the application of statistical methods to epidemiological studies.
Understanding and/or experience of complex datasets, including integration of health records or phenotypic data
Experience in managing and curating large and complex information resources – extraction, conversion, integration and data transfer.
Experience of working in a multidisciplinary team (e.g. a team involving clinicians, scientists, etc.) and/or in wider collaborative groups.
Our passion for diversity and equality means creating a work environment for all employees that is welcoming, respectful, engaging, and enriched with opportunities for personal and professional development.
What's On Offer
We have a range of benefits here at UK Biobank, some of the highlights of those are;
26 days annual leave (which increases with length of service) + bank holidays (including Christmas closure)
Holiday buy scheme (buy up to 1 week of additional leave per year)
A paid day off for your birthday (in addition to annual leave)
Flexible (hybrid) working, including modern offices in Stockport
Onsite canteen
Free lunches (£5 discount per day on orders in the on site canteen)
Free gym onsite
Free parking
USS Pension Scheme which is a 'hybrid' defined benefit/defined contribution scheme (9.8 % Employee Contribution, 21.6% Employer Contribution)
Enhanced family leave (available from day 1 of employment)
Employee discounts portal
Professional subscriptions reimbursed
Employee Assistance Programme
Eye-care Scheme
Annual Flu Vaccination
Life Assurance cover
Cycle to Work scheme
20% discount at EE
The job advert closing date may change, so we recommend that if you are planning to apply that you do so without delay.
About the Company
UK Biobank is a large-scale biomedical database and research resource containing genetic, lifestyle and health information from half a million UK participants. UK Biobank’s database, which includes blood samples, heart and brain scans and genetic data of the 500,000 volunteer participants, is globally accessible to approved researchers who are undertaking health-related research that’s in the public interest. UK Biobank recruited 500,000 people aged between 40-69 years in 2006-2010 from across the UK. With their consent, t... Know more
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